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Article

Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase.

Life science alliance - 1 Nov 2023

Franco Leticia Veloso R, Su Chen-Hsien, Simas Teixeira Lorisa, Almeida Clarck Chagas Jhulia, Barros Mario Henrique, Tzagoloff Alexander

Abstract excerpt

The Cox6 subunit of Saccharomyces cerevisiae cytochrome oxidase (COX) and the Atp9 subunit of the ATP synthase are encoded in nuclear and mitochondrial DNA, respectively. The two proteins interact to form Atco complexes that serve as the source of Atp9 for ATP synthase assembly. To determine if Atco is also a precursor of COX, we pulse-labeled Cox6 in isolated mitochondria of a cox6 nuclear mutant with COX6 in...

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Identifiers

PMID: 37604582
DOI: 10.26508/lsa.202301965
PMCID: PMC10442929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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