Article
Histo-Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy.
The Journal of infectious diseases - 11 Apr 2018
Lee Benjamin, Dickson Dorothy M, deCamp Allan C, Ross Colgate E, Diehl Sean A, Uddin Muhammad Ikhtear, Sharmin Salma, Islam Shahidul, Bhuiyan Taufiqur Rahman, Alam Masud, Nayak Uma, Mychaleckyj Josyf C, Taniuchi Mami, Petri William A, Haque Rashidul, Qadri Firdausi, Kirkpatrick Beth D
Abstract excerpt
Background: Lewis and secretor histo-blood group antigens (HBGAs) have been associated with decreased susceptibility to P[8] genotype rotavirus (RV) infections. Efficacy of vaccines containing attenuated P[8] strains is decreased in low-income countries. Host phenotype might impact vaccine efficacy (VE) by altering susceptibility to vaccination or RV diarrhea (RVD). We performed a substudy in a monovalent RV...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.