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Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018.

Scientific reports - 24 Apr 2020

Cantelli Carina Pacheco, Velloso Alvaro Jorge, Assis Rosane Maria Santos de, Barros José Júnior, Mello Francisco Campello do Amaral, Cunha Denise Cotrim da, Brasil Patricia, Nordgren Johan, Svensson Lennart, Miagostovich Marize Pereira, Leite José Paulo Gagliardi, Moraes Marcia Terezinha Baroni de

Abstract excerpt

Recent studies have investigated whether the human histo-blood group antigen (HBGAs) could affect the effectiveness of the oral rotavirus vaccines, suggesting secretor positive individuals develop a more robust response. We investigated the Rotavirus A (RVA) shedding in association with the host susceptibility profile in children from a birth community-cohort in Rio de Janeiro, Brazil, from 2014 to 2018. A total...

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PMID: 32332841
DOI: 10.1038/s41598-020-64025-0
PMCID: PMC7181595

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