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Article

Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients.

Nature communications - 6 Jul 2021

Jin Linlin, Sun Zimin, Liu Huilan, Zhu Xiaoyu, Zhou Yonggang, Fu Binqing, Zheng Xiaohu, Song Kaidi, Tang Baolin, Wu Yun, Zhu Jiang, Sun Rui, Tian Zhigang, Wei Haiming

Abstract excerpt

Unrelated cord blood transplantation (UCBT) is an effective treatment for hematopoietic disorders. However, this attractive approach is frequently accompanied by pre-engraftment syndrome (PES), severe cases of PES are associated with enhanced mortality and morbidity, but the pathogenesis of PES remains unclear. Here we show that GM-CSF produced by cord blood-derived inflammatory monocytes drives PES pathology,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34230468
DOI: 10.1038/s41467-021-24412-1
PMCID: PMC8260612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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