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Identification of genetic variants in m6A modification genes associated with pancreatic cancer risk in the Chinese population.

Archives of toxicology - 1 Mar 2021

Ying Pingting, Li Yao, Yang Nan, Wang Xiaoyang, Wang Haoxue, He Heng, Li Bin, Peng Xiating, Zou Danyi, Zhu Ying, Zhong Rong, Miao Xiaoping, Tian Jianbo, Chang Jiang

Abstract excerpt

N6-Methyladenosine (m6A) is the most prevalent modification of RNA in eukaryotes, and is associated with many cellular processes and even the development of cancers. We hypothesized that single-nucleotide polymorphisms (SNPs) in m6A modification genes, including its "writers", "erasers" and "readers", might affect the m6A functions and associate with the susceptibility to pancreatic ductal adenocarcinoma (PDAC)....

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PMID: 33474615
DOI: 10.1007/s00204-021-02978-5

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