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Article

Cross-species comparison of pregnancy-induced GDF15

16 Aug 2023

Abstract excerpt

In the present study pregnancy-induced changes in circulating growth differentiation factor 15 (GDF15) in rodents, rhesus macaques, and humans are mapped. In sum, it is demonstrated that humans and macaques exhibit a tremendous increase in placental and circulating GDF15 during pregnancy. In contrast, GDF15 is negligibly increased in pregnant mice and rats, questioning a physiological role for GDF15 in pregnancy...

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PMID: 37584611
DOI: 10.1152/ajpendo.00134.2023

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