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Assays with Patient-Derived Organoids to Evaluate the Impact of Microbial Infection on Base Excision Repair (BER) Enzymes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Sayed Ibrahim M, Chakraborty Anirban, Das Soumita

Abstract excerpt

Microbes play an important role in regulating cellular responses and the induction of chronic diseases. Infection and chronic inflammation can cause DNA damage, and the accumulation of mutations leads to cancer development. The well-known examples of cancer-associated microbes are Helicobacter pylori in gastric cancer and Fusobacterium nucleatum (Fn), Bacteroides fragilis, and E.coli NC101 in colorectal...

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PMID: 37574481
DOI: 10.1007/978-1-0716-3373-1_10

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