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Article

FANCA deficiency promotes leukaemic progression by allowing the emergence of cells carrying oncogenic driver mutations.

Oncogene - 1 Sept 2023

Pawlikowska Patrycja, Delestré Laure, Gregoricchio Sebastian, Oppezzo Alessia, Esposito Michela, Diop M' Boyba, Rosselli Filippo, Guillouf Christel

Abstract excerpt

Leukaemia is caused by the clonal evolution of a cell that accumulates mutations/genomic rearrangements, allowing unrestrained cell growth. However, recent identification of leukaemic mutations in the blood cells of healthy individuals revealed that additional events are required to expand the mutated clones for overt leukaemia. Here, we assessed the functional consequences of deleting the Fanconi anaemia A...

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Identifiers

PMID: 37573408
DOI: 10.1038/s41388-023-02800-9
PMCID: PMC10491493

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