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The relevance of the hematopoietic niche for therapy resistance in acute myeloid leukemia

11 Aug 2023

Abstract excerpt

The expansion of acute myeloid leukemia (AML) blasts not only suppresses normal hematopoiesis, but also alters the microenvironment. The interplay of different components of the bone marrow gives rise to altered metabolic states and activates signaling pathways which lead to resistance and impede effective therapy. Therefore, the underlying processes and mechanisms represent attractive therapeutic leverage points...

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PMID: 37565773
DOI: 10.1002/ijc.34684

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