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A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia

21 Oct 2021

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis and remarkable resistance to chemotherapeutic agents. Understanding resistance mechanisms against currently available drugs helps to recognize the therapeutic obstacles. Various mechanisms of resistance to chemotherapy or targeted inhibitors have been described for AML cells, including a role for the bone marrow niche in both the...

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PMID: 34831055
DOI: 10.3390/cells10112833

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