Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of severe vs mild GBA mutations on Parkinson disease.

Neurology - 3 Mar 2015

Gan-Or Ziv, Amshalom Idan, Kilarski Laura L, Bar-Shira Anat, Gana-Weisz Mali, Mirelman Anat, Marder Karen, Bressman Susan, Giladi Nir, Orr-Urtreger Avi

Abstract excerpt

OBJECTIVE: To better define the genotype-phenotype correlations between the type of GBA (glucosidase, beta, acid) mutation, severe or mild, and the risk and age at onset (AAO), and potential mechanism of Parkinson disease (PD). METHODS: We analyzed 1,000 patients of Ashkenazi-Jewish descent with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Cohort Studies
Share to Glucosylceramidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysosomal Storage Disorders Research

Share to Mutation

Share to Parkinson Disease

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 25653295
DOI: 10.1212/WNL.0000000000001315
PMCID: PMC4351661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25653295-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effects of severe vs mild GBA mutations on Parkinson disease.PMID 25653295Read ↗

Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset.Semantic proximity Read ↗

Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease.Semantic proximity Read ↗

Comparison of Parkinson risk in Ashkenazi Jewish patients with Gaucher disease and GBA heterozygotes.Semantic proximity Read ↗

GBA-Related Parkinson's Disease: Dissection of Genotype-Phenotype Correlates in a Large Italian Cohort.Semantic proximity Read ↗

Differential phenotype in Parkinson's disease patients with severe versus mild GBA mutationsSemantic proximity Read ↗

Exploring the Genotype–Phenotype Correlation in GBA-Parkinson Disease: Clinical Aspects, Biomarkers, and Potential ModifiersSemantic proximity Read ↗

Prevalence and genotype-phenotype correlations of GBA-related Parkinson disease in a large Chinese cohort.Semantic proximity Read ↗

Penetrance of Parkinson’s disease in<i>GBA1</i>carriers is depending on the variant severity and polygenic backgroundSemantic proximity Read ↗

Severe<i>GBA1</i>variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trialsSemantic proximity Read ↗

Age-specific Parkinson disease risk in GBA mutation carriers: information for genetic counseling.Semantic proximity Read ↗

Parkinson's disease phenotype is influenced by the severity of the mutations in the GBA gene.Semantic proximity Read ↗

Genetic mechanism vs genetic subtypes: The example of GBA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.