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Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysis

15 May 2025

Abstract excerpt

Small cell carcinoma of the esophagus (SCCE) is an aggressive and rare neuroendocrine malignancy with poor prognosis. Here, we firstly performed single-cell transcriptional profiling derived from 10 SCCE patients, with normal esophageal mucosa, adjacent non-malignant tissue and tumors from esophageal squamous cell carcinoma (ESCC) as reference. We observed enrichment of activated regulatory T cells and an...

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PMID: 40375239
DOI: 10.1186/s12943-025-02335-5

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