Article
Exome sequencing to explore the possibility of predicting genetic susceptibility to the joint occurrence of polycystic ovary syndrome and Hashimoto's thyroiditis.
Frontiers in immunology - 1 Jan 2023
Zeber-Lubecka Natalia, Suchta Katarzyna, Kulecka Maria, Kluska Anna, Piątkowska Magdalena, Dabrowski Michal J, Jankowska Katarzyna, Grymowicz Monika, Smolarczyk Roman, Hennig Ewa E
Abstract excerpt
A large body of evidence indicates that women with polycystic ovary syndrome (PCOS) have a higher risk of developing Hashimoto's thyroiditis (HT) than healthy individuals. Given the strong genetic impact on both diseases, common predisposing genetic factors are possibly involved but are not fully understood. Here, we performed whole-exome sequencing (WES) for 250 women with sporadic PCOS, HT, combined PCOS and HT...
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