Article
Evaluation of HIV-1 antiretroviral drug resistance profiles in the peripheral blood reservoir of successfully treated persons using massive sequencing and viral full genome characterization.
The Journal of antimicrobial chemotherapy - 1 Jun 2023
Botelho Ornella M, Basso Rossana P, Da Mota Luisa D, Da Hora Vanusa P, Garrido Marianne M, Machado Elizabeth S, Alves Brunna M, Soares Marcelo A
Abstract excerpt
BACKGROUND: Antiretroviral therapy has revolutionized HIV treatment, increasing quality and life expectancy of people living with HIV (PLWH). However, the expansion of treatment has resulted in an increase in antiretroviral-resistant viruses, which can be an obstacle to maintenance of successful ART. OBJECTIVES: This study analysed the genetic composition of the HIV near full-length genome (NFLG) from archived...
Topics
- Humans
- HIV-1
- Phylogeny
- Brazil
- Anti-Retroviral Agents
- HIV Infections
- HIV Seropositivity
- Mutation
- Proviruses
- Drug Resistance, Viral