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Production of retroviral vectors in continuous high cell density culture

5 Aug 2023

Abstract excerpt

Retroviral vectors derived from murine leukemia virus (MLV) are used in somatic gene therapy applications e.g. for genetic modification of hematopoietic stem cells. Recently, we reported on the establishment of a suspension viral packaging cell line (VPC) for the production of MLV vectors. Human embryonic kidney 293-F (HEK293-F) cells were genetically modified for this purpose using transposon vector technology....

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CAR-T cell therapy research
CRISPR and Genetic Engineering
Virus-based gene therapy research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37542575
DOI: 10.1007/s00253-023-12689-9

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