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Article

Improved Methods of Retroviral Vector Transduction and Production for Gene Therapy

1 Jan 1994

Abstract excerpt

To facilitate clinical applications of retroviral-mediated human gene transfer, retroviral vectors must be of high titer and free of detectable replication-competent retroviruses. The purpose of this study was to optimize methods of retroviral vector production and transduction. Studies were conducted using 22 retroviral vector producer cell lines. Inactivation of retroviral vectors was greater at 37°C than at...

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Identifiers

PMID: 8155767
DOI: 10.1089/hum.1994.5.1-19

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