Article
O-GlcNAc Modification Alters the Chaperone Activity of HSP27 Charcot-Marie-Tooth Type 2 (CMT2) Variants in a Mutation-Selective Fashion.
ACS chemical biology - 18 Aug 2023
Moon Stuart P, Wang Binyou, Ahn Benjamin S, Ryu Andrew H, Hard Eldon R, Javed Afraah, Pratt Matthew R
Abstract excerpt
Increased O-GlcNAc is a common feature of cellular stress, and the upregulation of this dynamic modification is associated with improved survival under these conditions. Likewise, the heat shock proteins are also increased under stress and prevent protein misfolding and aggregation. We previously linked these two phenomena by demonstrating that O-GlcNAc directly increases the chaperone of certain small heat shock...
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