Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Oct 2011

Almeida-Souza Leonardo, Asselbergh Bob, d'Ydewalle Constantin, Moonens Kristof, Goethals Sofie, de Winter Vicky, Azmi Abdelkrim, Irobi Joy, Timmermans Jean-Pierre, Gevaert Kris, Remaut Han, Van Den Bosch Ludo, Timmerman Vincent, Janssens Sophie

Abstract excerpt

Mutations in the small heat shock protein HSPB1 (HSP27) are causative for Charcot-Marie-Tooth (CMT) neuropathy. We previously showed that a subset of these mutations displays higher chaperone activity and enhanced affinity to client proteins. We hypothesized that this excessive binding property might cause the HSPB1 mutant proteins to disturb the function of proteins essential for the maintenance or survival of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ganglia, Spinal
Share to HSP27 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubules

Share to Nocodazole

Share to Surface Plasmon Resonance

Share to Tandem Mass Spectrometry

Share to Tubulin

Share to Tubulin Modulators

Source

Open in PubMed Open full text

Identifiers

PMID: 22031878
DOI: 10.1523/JNEUROSCI.3266-11.2011
PMCID: PMC6703512

Genes

HSPB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy.PMID 22031878Read ↗

A Charcot-Marie-Tooth-Causing Mutation in HSPB1 Decreases Cell Adaptation to Repeated Stress by Disrupting Autophagic Clearance of Misfolded Proteins.Semantic proximity Read ↗

Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy.Semantic proximity Read ↗

Mutations in HspB1 and hereditary neuropathies.Semantic proximity Read ↗

Stress-Driven Selective Neuronal Vulnerability in Charcot-Marie-Tooth Disease: From Prodromal Pathology to Therapeutic Implications.Semantic proximity Read ↗

Novel insights in the disease biology of mutant small heat shock proteins in neuromuscular diseases.Semantic proximity Read ↗

Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases.Semantic proximity Read ↗

Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice.Semantic proximity Read ↗

Mutations in heat shock protein beta-1 (HSPB1) are associated with a range of clinical phenotypes related to different patterns of motor neuron dysfunction: A case series.Semantic proximity Read ↗

HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cellsSemantic proximity Read ↗

A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes.Semantic proximity Read ↗

Neuronal diseases: small heat shock proteins calm your nerves.Semantic proximity Read ↗

Small heat shock proteins in neurodegenerative diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.