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Article

Protein glycosylation: chaperone mutation in Tn syndrome.

Nature - 27 Oct 2005

Ju Tongzhong, Cummings Richard D

Abstract excerpt

Tn syndrome is a rare autoimmune disease in which subpopulations of blood cells in all lineages carry an incompletely glycosylated membrane glycoprotein, known as the Tn antigen. This truncated antigen has the sugar N-acetylgalactosamine alpha-linked to either a serine or threonine amino-acid residue, whereas the correct T antigen has an additional terminal galactose; the defect may be due to a malfunction of the...

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Identifiers

PMID: 16251947
DOI: 10.1038/4371252a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Protein glycosylation: chaperone mutation in Tn syndrome.PMID 16251947Read ↗

Germline C1GALT1C1 mutation causes a multisystem chaperonopathy.Semantic proximity Read ↗

Cosmc is an essential chaperone for correct protein O-glycosylation.Semantic proximity Read ↗

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.Semantic proximity Read ↗

Germline C1GALT1C1 Mutation Causes a Multisystemic Chaperonopathy with Global Deficiency of Core 1-derived O-GlycosylationSemantic proximity Read ↗

New mutations in C1GALT1C1 in individuals with Tn positive phenotype.Semantic proximity Read ↗

Functional assays for the molecular chaperone cosmc.Semantic proximity Read ↗

Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in <i>Cosmc</i>Semantic proximity Read ↗

No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients.Semantic proximity Read ↗

Cosmc-dependent mucin-type O-linked glycosylation is essential for podocyte function.Semantic proximity Read ↗

A mutant chaperone converts a wild-type protein into a tumor-specific antigen.Semantic proximity Read ↗

Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy.Semantic proximity Read ↗

Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29.Semantic proximity Read ↗

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