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Article

The synergistic effect of IDH mutation and NDRG-2 dysregulation in the progression of WHO-grade 4 astrocytomas.

Pathology, research and practice - 1 Aug 2023

Kurdi Maher, Fadul Motaz M, Alkhayyat Shadi, Sabbagh Abdulrahman J, Alsinani Taghreed, Alkhotani Alaa, Mulla Nasser, Mehboob Riffat, Fathaddin Amany A, Bamaga Ahmed, Faizo Eyad, Baeesa Saleh

Abstract excerpt

BACKGROUND: NDRG2 is a tumour suppressor gene involved in tumor growth inhibition. Its effect on tumour recurrence remains controversial. The aim of this study is to explore the dual effect of IDH mutation and NDRG2 dysregulation in WHO-Grade 4 astrocytoma recurrence. METHODS: A group of 36 patients with WHO-Grade 4 astrocytoma were examined for NDRG2 expression using protein and gene expression assays. The...

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Astrocytoma
Brain Neoplasms
Disease Progression
Gene Expression Regulation, Neoplastic
Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

Neoplasm Recurrence, Local

Tumor Suppressor Proteins

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Identifiers

PMID: 37536020
DOI: 10.1016/j.prp.2023.154733

Genes

NDRG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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