Article
The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory.
Oncology research - 1 Jan 2024
Kurdi Maher, Alkhotani Alaa, Sabbagh Abdulrahman, Faizo Eyad, Lary Ahmed I, Bamaga Ahmed K, Almansouri Majid, Hafiz Badr, Alsharif Thamer, Baeesa Saleh
Abstract excerpt
Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods:...
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