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CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers

3 Aug 2023

Abstract excerpt

Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we focused on tumor-to-tumor variation to examine 52 head and neck squamous cell carcinomas. We found that macrophage polarity—defined by CXCL9 and SPP1 (CS) expression but not by...

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PMID: 37535729
DOI: 10.1126/science.ade2292

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