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Article

Shared Gene Targets of the ATF4 and p53 Transcriptional Networks

2 Aug 2023

Abstract excerpt

The master tumor suppressor p53 regulates multiple cell fate decisions, such as cell cycle arrest and apoptosis, via transcriptional control of a broad gene network. Dysfunction in the p53 network is common in cancer, often through mutations that inactivate p53 or other members of the pathway. Induction of tumor-specific cell death by restoration of p53 activity without off-target effects has gained significant...

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PMID: 37533313
DOI: 10.1080/10985549.2023.2229225

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