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Article

Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model.

Experimental cell research - 10 Dec 2015

Lenčo Juraj, Lenčová-Popelová Olga, Link Marek, Jirkovská Anna, Tambor Vojtěch, Potůčková Eliška, Stulík Jiří, Šimůnek Tomáš, Štěrba Martin

Abstract excerpt

Due to their cardiac origin, H9c2 cells rank among the most popular cell lines in current cardiovascular research, yet molecular phenotype remains elusive. Hence, in this study we used proteomic approach to describe molecular phenotype of H9c2 cells in their undifferentiated (i.e., most frequently used) state, and its functional response to cardiotoxic drug doxorubicin. Of 1671 proteins identified by iTRAQ...

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PMID: 26515555
DOI: 10.1016/j.yexcr.2015.10.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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