Article
Systematic transcriptomic and phenotypic characterization of human and murine cardiac myocyte cell lines and primary cardiomyocytes reveals serious limitations and low resemblances to adult cardiac phenotype.
Journal of molecular and cellular cardiology - 1 Apr 2022
Onódi Zsófia, Visnovitz Tamás, Kiss Bernadett, Hambalkó Szabolcs, Koncz Anna, Ágg Bence, Váradi Barnabás, Tóth Viktória É, Nagy Regina N, Gergely Tamás G, Gergő Dorottya, Makkos András, Pelyhe Csilla, Varga Nóra, Reé Dóra, Apáti Ágota, Leszek Przemyslaw, Kovács Tamás, Nagy Nándor, Ferdinandy Péter, Buzás Edit I, Görbe Anikó, Giricz Zoltán, Varga Zoltán V
Abstract excerpt
BACKGROUND: Cardiac cell lines and primary cells are widely used in cardiovascular research. Despite increasing number of publications using these models, comparative characterization of these cell lines has not been performed, therefore, their limitations are undetermined. We aimed to compare cardiac cell lines to primary cardiomyocytes and to mature cardiac tissues in a systematic manner. METHODS AND RESULTS:...
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