Article
Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.
Journal of virology - 31 Oct 2023
Schulz Vanessa E, Tuff Jeffrey F, Tough Riley H, Lewis Lara, Chimukangara Benjamin, Garrett Nigel, Abdool Karim Quarraisha, Abdool Karim Salim S, McKinnon Lyle R, Kharsany Ayesha B M, McLaren Paul J
Abstract excerpt
IMPORTANCE: It has been previously shown that genetic variants near CHD1L on chromosome 1 are associated with reduced HIV VL in African populations. However, the impact of these variants on viral diversity and how they restrict viral replication are unknown. We report on a regional association analysis in a South African population and show evidence of selective pressure by variants near CHD1L on HIV RT and gag....
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