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Article

Predictive value of homologous recombination-related gene mutations in survival outcomes of first-line nivolumab plus chemotherapy for gastric cancer.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Nov 2025

Lee Yuna, Kim Hyung-Don, Lee Sun Young, Lee Hyungeun, Hyung Jaewon, Moon Meesun, Shin Jinho, Park Young Soo, Kim Tae Won, Ryu Min-Hee

Abstract excerpt

BACKGROUND: Homologous recombination repair (HRR) gene mutations contribute to genomic instability. However, their clinical value in immune checkpoint inhibitor (ICI)-based treatments in gastric cancer remains unclear. Therefore, this study aims to investigate the efficacy of nivolumab plus chemotherapy according to the HRR mutation status in patients with advanced gastric cancer. METHODS: This single-center...

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Identifiers

PMID: 40719786
DOI: 10.1007/s10120-025-01648-0

Genes

BRCA2
BARD1
BLM
BRCA1
BRIP1
NBN
PALB2
PARP1
POLD1
RAD50
RAD51
RAD51C
RAD51D
RAD52
RAD54L
XRCC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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