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The largest HIV-1-infected T cell clones in children on long-term combination antiretroviral therapy contain solo LTRs

2 Aug 2023

Abstract excerpt

Combination antiretroviral therapy (cART) suppresses viral replication but does not cure HIV infection because a reservoir of infectious (intact) HIV proviruses persists in long-lived CD4+T cells. However, a large majority (>95%) of HIV-infected cells that persist on effective cART carry defective (non-infectious) proviruses. Defective proviruses consisting of only a single LTR (solo long terminal repeat) are...

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PMID: 37530525
DOI: 10.1128/mbio.01116-23

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