Ebola virus shed glycoprotein is toxic to human T, B, and natural killer lymphocytes

Abstract excerpt

Lymphocyte depletion is a distinctive feature of Ebola virus (EBOV) disease. The ectodomain of EBOV glycoprotein (GP) is cleaved off the surface of infected cells into circulation as shed GP. To test the hypothesis that shed GP induces lymphocyte death, we cultured primary human B, NK, or T cells with shed GP in vitro . We found that shed GP dependably decreased B, NK, and T cell viability across donors. B and NK...

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