Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity.

Science (New York, N.Y.) - 9 Mar 2001

Volchkov V E, Volchkova V A, Muhlberger E, Kolesnikova L V, Weik M, Dolnik O, Klenk H D

Abstract excerpt

To study the mechanisms underlying the high pathogenicity of Ebola virus, we have established a system that allows the recovery of infectious virus from cloned cDNA and thus permits genetic manipulation. We created a mutant in which the editing site of the gene encoding envelope glycoprotein (GP) was eliminated. This mutant no longer expressed the nonstructural glycoprotein sGP. Synthesis of GP increased, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Cytopathogenic Effect, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ebolavirus

Share to Glycoproteins

Share to RNA Editing

Share to Vero Cells

Share to Viral Envelope Proteins

Share to Viral Proteins

Source

Identifiers

PMID: 11239157
DOI: 10.1126/science.1057269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity.PMID 11239157Read ↗

RNA Editing of the GP Gene of Ebola Virus is an Important Pathogenicity Factor.Semantic proximity Read ↗

A New Ebola Virus Nonstructural Glycoprotein Expressed through RNA EditingSemantic proximity Read ↗

Reverse Genetics Demonstrates that Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Essential for Replication in Cell CultureSemantic proximity Read ↗

An Improved Reverse Genetics System to Overcome Cell-Type-Dependent Ebola Virus Genome Plasticity.Semantic proximity Read ↗

Less Is More: Ebola Virus Surface Glycoprotein Expression Levels Regulate Virus Production and InfectivitySemantic proximity Read ↗

Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate levelSemantic proximity Read ↗

Production of Novel Ebola Virus-Like Particles from cDNAs: an Alternative to Ebola Virus Generation by Reverse GeneticsSemantic proximity Read ↗

A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: generation of a novel copy‐back nondefective interfering virus.Semantic proximity Read ↗

Genomic RNA Editing and Its Impact on Ebola Virus Adaptation During Serial Passages in Cell Culture and Infection of Guinea PigsSemantic proximity Read ↗

Comprehensive Analysis of Ebola Virus GP1 in Viral EntrySemantic proximity Read ↗

Molecular cloning of natural paramyxovirus copy-back defective interfering RNAs and their expression from DNASemantic proximity Read ↗

Efficient Rescue of Infectious Bursal Disease Virus from Cloned cDNA: Evidence for Involvement of the 3′-Terminal Sequence in Genome ReplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.