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Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection

24 Oct 2019

Abstract excerpt

Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly correlative with fatalities.However, the mechanisms leading to T-cell depletion remain largely unknown.Here, we demonstrate that both viral mRNAs and antigens are detectable in CD4 + T cells despite the absence of productive infection.A protein phosphatase 1 inhibitor, 1E7-03, and siRNA-mediated suppression of viral...

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PMID: 31648236
DOI: 10.1371/journal.ppat.1008068

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