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Article

Chinese hamster ovary cell lines selected for resistance to ebolavirus glycoprotein mediated infection are defective for NPC1 expression.

Virology - 10 Oct 2012

Haines Kathleen M, Vande Burgt Nathan H, Francica Joseph R, Kaletsky Rachel L, Bates Paul

Abstract excerpt

Ebolavirus causes severe hemorrhagic fever in humans and non-human primates. Entry of ebolavirus is mediated by the viral glycoprotein, GP; however, the required host factors have not been fully elucidated. A screen utilizing a recombinant Vesicular Stomatitis Virus (VSV) encoding Zaire ebolavirus GP identified four Chinese Hamster Ovary (CHO) cell lines resistant to GP-mediated viral entry. Susceptibility to...

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Identifiers

PMID: 22726751
DOI: 10.1016/j.virol.2012.05.018
PMCID: PMC3402687

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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