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Article

DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma.

Clinical epigenetics - 2 Aug 2023

Kerdivel Gwenneg, Amrouche Floriane, Calmejane Marie-Ange, Carallis Floriane, Hamroune Juliette, Hantel Constanze, Bertherat Jérôme, Assié Guillaume, Boeva Valentina

Abstract excerpt

BACKGROUND: Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently described subtype characterized by a CpG island methylator phenotype (CIMP) has been associated with an especially poor prognosis. However, the drivers of CIMP remain unknown. Furthermore, the functional relation between CIMP and poor clinical outcomes of patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37528470
DOI: 10.1186/s13148-023-01534-5
PMCID: PMC10394822

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