Article
DNA methylation profiling identifies global methylation differences and markers of adrenocortical tumors.
The Journal of clinical endocrinology and metabolism - 1 Jun 2012
Rechache Nesrin S, Wang Yonghong, Stevenson Holly S, Killian J Keith, Edelman Daniel C, Merino Maria, Zhang Lisa, Nilubol Naris, Stratakis Constantine A, Meltzer Paul S, Kebebew Electron
Abstract excerpt
CONTEXT: It is not known whether there are any DNA methylation alterations in adrenocortical tumors. OBJECTIVE: The objective of the study was to determine the methylation profile of normal adrenal cortex and benign and malignant adrenocortical tumors. METHODS: Genome-wide methylation status of CpG regions were determined in normal (n = 19), benign (n = 48), primary malignant (n = 8), and metastatic malignant (n...
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