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Article

Identification of a CpG island methylator phenotype in adrenocortical carcinomas.

The Journal of clinical endocrinology and metabolism - 1 Jan 2013

Barreau Olivia, Assié Guillaume, Wilmot-Roussel Hortense, Ragazzon Bruno, Baudry Camille, Perlemoine Karine, René-Corail Fernande, Bertagna Xavier, Dousset Bertrand, Hamzaoui Nadim, Tissier Frédérique, de Reynies Aurélien, Bertherat Jérôme

Abstract excerpt

PURPOSE: DNA methylation is a mechanism for gene expression silencing in cancer. Limited information is available for adrenocortical tumors. Abnormal methylation at the IGF2/H19 locus is common in adrenocortical carcinomas. Our aim was to characterize the methylation in adrenocortical carcinomas at a whole-genome scale and to assess its clinical significance and its impact on gene expression. EXPERIMENTAL DESIGN:...

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Share to Adrenal Gland Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23093492
DOI: 10.1210/jc.2012-2993

Genes

IGF2
NDRG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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