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Article

A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram.

Clinical pharmacology and therapeutics - 1 Sept 2021

Bråten Line Skute, Haslemo Tore, Jukic Marin M, Ivanov Maxim, Ingelman-Sundberg Magnus, Molden Espen, Kringen Marianne Kristiansen

Abstract excerpt

Escitalopram is one of the most commonly used antidepressant drugs but exhibits a substantial interindividual variation in clinical response. A key factor underlying response differences is the polymorphic nature of the CYP2C19 gene encoding the major enzyme responsible for escitalopram metabolism. Although pre-emptive CYP2C19 genotyping may improve escitalopram treatment outcome by dose individualization, much...

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Source

Identifiers

PMID: 33759177
DOI: 10.1002/cpt.2233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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