Article
The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma.
British journal of cancer - 17 May 2004
Linnebank M, Schmidt S, Kölsch H, Linnebank A, Heun R, Schmidt-Wolf I G H, Glasmacher A, Fliessbach K, Klockgether T, Schlegel U, Pels H
Abstract excerpt
Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26,...
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