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Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

30 Jul 2023

Abstract excerpt

Clostridioides difficile produces toxins that damage the colonic epithelium, causing colitis. Variation in disease severity is poorly understood and has been attributed to host factors and virulence differences between C. difficile strains. We test 23 epidemic ST1 C. difficile clinical isolates for their virulence in mice. All isolates encode a complete Tcd pathogenicity locus and achieve similar colonization...

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PMID: 37523264
DOI: 10.1016/j.celrep.2023.112861

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