Article
Epigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling.
Cell death & disease - 29 Jul 2023
Sun Xinpei, Li Qian, Tang Yunyi, Hu Wanjin, Chen Gengyao, An Hongguang, Huang Daoyuan, Tong Tanjun, Zhang Yu
Abstract excerpt
Although metabolic reprogramming is characterized as a hallmark of aging, implications of the crucial glutamate dehydrogenase (GDH) in human senescence remain poorly understood. Here, we report that GDH activity is significantly increased in aged mice and senescent human diploid fibroblasts. This enzymatic potentiation is associated with de-repression of GDH from its functionally suppressive ADP-ribosylation...
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