Article
Added Value of Next Generation Sequencing in Characterizing the Evolution of HIV-1 Drug Resistance in Kenyan Youth.
Viruses - 22 Jun 2023
Novitsky Vlad, Nyandiko Winstone, Vreeman Rachel, DeLong Allison K, Howison Mark, Manne Akarsh, Aluoch Josephine, Chory Ashley, Sang Festus, Ashimosi Celestine, Jepkemboi Eslyne, Orido Millicent, Hogan Joseph W, Kantor Rami
Abstract excerpt
Drug resistance remains a global challenge in children and adolescents living with HIV (CALWH). Characterizing resistance evolution, specifically using next generation sequencing (NGS) can potentially inform care, but remains understudied, particularly in antiretroviral therapy (ART)-experienced CALWH in resource-limited settings. We conducted reverse-transcriptase NGS and investigated short-and long-term...
Topics
- High-Throughput Nucleotide Sequencing
- HIV-1
- HIV Seropositivity
- Adolescent
- Muscular Dystrophies
- Child
- Kenya
- HIV Infections
- Mutation
- Humans