Article
Neutral Forces and Balancing Selection Interplay to Shape the Major Histocompatibility Complex Spatial Patterns in the Striped Hamster in Inner Mongolia: Suggestive of Broad-Scale Local Adaptation.
Genes - 22 Jul 2023
Liu Pengbo, Li Guichang, Zhao Ning, Song Xiuping, Wang Jun, Shi Xinfei, Wang Bin, Zhang Lu, Dong Li, Li Qingduo, Liu Qiyong, Lu Liang
Abstract excerpt
BACKGROUND: The major histocompatibility complex (MHC) plays a key role in the adaptive immune response to pathogens due to its extraordinary polymorphism. However, the spatial patterns of MHC variation in the striped hamster remain unclear, particularly regarding the relative contribution of the balancing selection in shaping MHC spatial variation and diversity compared to neutral forces. METHODS: In this study,...
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