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Article

MHC-I diversity enables rapid adaptation during a viral pandemic in wild rabbit populations.

Proceedings of the National Academy of Sciences of the United States of America - 19 May 2026

Zhang Yexin, Day Jonathan P, Lirintzi Marina, Ji Jiayi, Tregaskes Clive A, Carneiro Miguel, Alves Joel M, Strive Tanja, Kaufman Jim, Jiggins Francis M

Abstract excerpt

Emerging diseases can have devastating consequences for wild species, with long-term effects depending on the ability of the host to evolve resistance. Here, we show that major histocompatibility complex (MHC) genes provided standing genetic variation that enabled rabbits to mount a rapid evolutionary response to the myxoma virus pandemic that began in the 1950s. Using historical and modern specimens starting in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42113988
DOI: 10.1073/pnas.2532064123
PMCID: PMC13187713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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