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Article

TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study.

Journal of negative results in biomedicine - 25 Nov 2010

Blaut Magda A, Bogdanova Natalia V, Bremer Michael, Karstens Johann H, Hillemanns Peter, Dörk Thilo

Abstract excerpt

The DNA double strand break repair gene TOPBP1 has been suggested as a breast cancer susceptibility gene and a missense variant Arg309Cys was observed at elevated frequency in familial breast cancer cases compared to healthy controls from Finland. We found the Arg309Cys allele at a 13% carrier frequency in a hospital-based series of 1064 German breast cancer patients and at a 14% carrier frequency in 1014...

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Source

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Identifiers

PMID: 21108795
DOI: 10.1186/1477-5751-9-9
PMCID: PMC3002300

Genes

TOPBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study.PMID 21108795Read ↗

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Genetic polymorphisms of TP53-binding protein 1 (TP53BP1) gene and association with breast cancer risk.Semantic proximity Read ↗

ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a German population.Semantic proximity Read ↗

Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer.Semantic proximity Read ↗

BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study.Semantic proximity Read ↗

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