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Article

Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer.

Breast cancer research and treatment - 1 Feb 2017

Radmanesh Hoda, Spethmann Tessa, Enßen Julia, Schürmann Peter, Bhuju Sabin, Geffers Robert, Antonenkova Natalia, Khusnutdinova Elza, Sadr-Nabavi Ariane, Shandiz Fatemeh Homaei, Park-Simon Tjoung-Won, Hillemanns Peter, Christiansen Hans, Bogdanova Natalia, Dörk Thilo

Abstract excerpt

PURPOSE: APOBEC3B belongs to the family of DNA-editing enzymes. A copy number variant targeting the genomic APOBEC3A-APOBEC3B locus has a significant impact on breast cancer risk, but the relative contribution of APOBEC3B is uncertain. In this study, we investigate a loss-of-function mutation that selectively targets APOBEC3B, for its association with breast cancer risk. METHODS: We performed exome sequencing on...

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Identifiers

PMID: 28062980
DOI: 10.1007/s10549-016-4100-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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