Article
Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity.
Biomolecules - 14 Jul 2023
Groppe Jay C, Lu Guorong, Tandang-Silvas Mary R, Pathi Anupama, Konda Shruti, Wu Jingfeng, Le Viet Q, Culbert Andria L, Shore Eileen M, Wharton Kristi A, Kaplan Frederick S
Abstract excerpt
Although structurally similar to type II counterparts, type I or activin receptor-like kinases (ALKs) are set apart by a metastable helix-loop-helix (HLH) element preceding the protein kinase domain that, according to a longstanding paradigm, serves passive albeit critical roles as an inhibitor-to-substrate-binding switch. A single recurrent mutation in the codon of the penultimate residue, directly adjacent the...
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