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Article

Reduced GS Domain Serine/Threonine Requirements of Fibrodysplasia Ossificans Progressiva Mutant Type I BMP Receptor ACVR1 in the Zebrafish.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2023

Allen Robyn S, Jones William D, Hale Maya, Warder Bailey N, Shore Eileen M, Mullins Mary C

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic condition characterized by altered skeletal development and extraskeletal bone formation. All cases of FOP are caused by mutations in the type I bone morphogenetic protein (BMP) receptor gene ACVR1 that result in overactivation of the BMP signaling pathway. Activation of the wild-type ACVR1 kinase requires assembly of a tetrameric type I and II...

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PMID: 37329499
DOI: 10.1002/jbmr.4869
PMCID: PMC11472394

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Reduced GS Domain Serine/Threonine Requirements of Fibrodysplasia Ossificans Progressiva Mutant Type I BMP Receptor ACVR1 in the Zebrafish.PMID 37329499Read ↗

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