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Article

Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.

The Journal of biological chemistry - 1 Sept 2023

Hussain Mansoor, Mohammed Aftab, Saifi Shabnam, Priya Swati, Sengupta Sagar

Abstract excerpt

Mutations in the DNA helicase RECQL4 lead to Rothmund-Thomson syndrome (RTS), a disorder characterized by mitochondrial dysfunctions, premature aging, and genomic instability. However, the mechanisms by which these mutations lead to pathology are unclear. Here we report that RECQL4 is ubiquitylated by a mitochondrial E3 ligase, MITOL, at two lysine residues (K1101, K1154) via K6 linkage. This ubiquitylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37495109
DOI: 10.1016/j.jbc.2023.105087
PMCID: PMC10470078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.PMID 37495109Read ↗

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stressSemantic proximity Read ↗

RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome.Semantic proximity Read ↗

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replicationSemantic proximity Read ↗

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.Semantic proximity Read ↗

The versatile RECQL4.Semantic proximity Read ↗

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stabilitySemantic proximity Read ↗

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.Semantic proximity Read ↗

RecQL4 regulates autophagy and apoptosis in U2OS cells.Semantic proximity Read ↗

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.Semantic proximity Read ↗

Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders.Semantic proximity Read ↗

Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.Semantic proximity Read ↗

An overview of RecQ helicases and related diseases.Semantic proximity Read ↗

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