Article
RecQL4 regulates autophagy and apoptosis in U2OS cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Dec 2016
Duan Yangmiao, Fang Hongbo
Abstract excerpt
RecQL4, one of the 5 human RecQ helicases, is a key mediator of genomic stability and its deficiency can cause premature aging phenotypes. Here, by using CRISPR/Cas and RNAi technology, we demonstrated that autophagy level was elevated in both RecQL4 knockdown and knockout cells compared with those of the control cells. Surprisingly, mitochondrial content was increased and LC3 co-localization with mitochondria...
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