Article

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication

2025-07-21

Abstract excerpt

RECQL4 is a member of the RecQ family of helicases, playing essential roles in DNA replication and maintaining genome integrity. Mutations in RECQL4 are linked to severe human diseases, including Rothmund-Thomson Syndrome, RAPIDALINO Syndrome, and Baller-Gerold Syndrome. However, we still do not fully understand its functions and genetic interactions. The role of the ATP-dependent helicase activity in RECQL4 remai...

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Literature Corpus work: 4d59265f-a86b-5e93-8454-3337903a03d1
DOI: 10.1101/2025.07.21.666025

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