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Article

Genetic Markers of Therapeutic Efficacy of Methotrexate in Patients with Psoriasis.

Bulletin of experimental biology and medicine - 1 Feb 2022

Voron'ko O E, Baskaev K K, Sobolev V V, Denisova E V, Korsunskaya I M

Abstract excerpt

We studied the effect of C677T and A1298C polymorphisms of the MTHFR gene and 2R/3R polymorphisms of the TYMS gene on the sensitivity to methotrexate in patients with psoriasis (n=139). It was shown that genotype 3R/3R TYMS (OR 8.86, 95%CI 2.00-39.22) and complex genotypes MTHFR1298:A;TYMS:3R (OR 8.20, 95%CI 2.36-28.48) and MTHFR677:C;TYMS:3R (OR 5.40, 95%CI 1.95-14.94) were associated with sensitivity to...

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Source

Identifiers

PMID: 35175470
DOI: 10.1007/s10517-022-05413-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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